Acteurs et actrices

Justin Long = Matthew "Matt" Farrell

Maggie Q = Mai Linh

Cliff Curtis = Miguel Bowman (FBI)

Bruce Willis = John McClane (père de Lucy)

Mary Elizabeth Winstead = Lucy Gennaro McClane (fille de John)

Timothy Olyphant = Thomas Gabriel

Christina Chang = Taylor

Zelijko Ivanek = Agent Molina

Yancey Arias = Agent spécial Johnson 

Edoardo Costa = Emerson

Yorgo Constantine = Russo

Kevin Smith = Frederick Kaludis

Sung Kang = Raj

Gerald Downey = Agent Hoover

Acteurs et actrices

Angelina Jolie = Lara Croft 

Simon Yam = Chen Lo

Terence Yin = Xien

Gerard Butler = Terry Sheridan

Djimon Hounsou = Kosa

Ciaran Hinds = Jonathan Reiss 

Chris Barrie = Hillary

Noah Taylor = Bryce

Til Schweiger = Sean 

Robert Cavanh = Agent Stevens M16

Ronan Vibert = Agent Calloway M16